Is useful research data usually shared? An investigation of genome-wide association study summary statistics
نویسندگان
چکیده
منابع مشابه
Title : Across - cohort QC analyses of genome - wide association study summary statistics from complex traits
7 Affiliations: 8 1 Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia 9 2 School of Environmental and Rural Science, The University of New England, Armidale, New South 10 Walsh, Australia 11 3 SPLUS Game, Guangzhou, Guangdong, China 12 4 Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of 13 Regensburg, Reg...
متن کاملReproduction and In-Depth Evaluation of Genome-Wide Association Studies and Genome-Wide Meta-analyses Using Summary Statistics
In line with open-source genetics, we report a novel linear regression technique for genome-wide association studies (GWAS), called Open GWAS algoriTHm (OATH). When individual-level data are not available, OATH can not only completely reproduce reported results from an experimental model, but also recover underreported results from other alternative models with a different combination of nuisan...
متن کاملMultivariate Analysis of Anthropometric Traits Using Summary Statistics of Genome-Wide Association Studies from GIANT Consortium
Meta-analysis of single trait for multiple cohorts has been used for increasing statistical power in genome-wide association studies (GWASs). Although hundreds of variants have been identified by GWAS, these variants only explain a small fraction of phenotypic variation. Cross-phenotype association analysis (CPASSOC) can further improve statistical power by searching for variants that contribut...
متن کاملmetaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis
MOTIVATION A dominant approach to genetic association studies is to perform univariate tests between genotype-phenotype pairs. However, analyzing related traits together increases statistical power, and certain complex associations become detectable only when several variants are tested jointly. Currently, modest sample sizes of individual cohorts, and restricted availability of individual-leve...
متن کاملSupplement to “bayesian Large-scale Multiple Regression with Summary Statistics from Genome-wide Association Studies”
A Theoretical derivation of RSS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 A.1 Proofs of propositions in main text . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 A.1.1 Proof of Proposition 2.1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 A.1.2 Proof of Proposition 2.2 . . . . . . . . . . . . . . ....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS ONE
سال: 2020
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0229578